Aplicación de la tecnología de membrana en la separación y concentración de heparina sódica

Antecedentes
La heparina sódica es un anticoagulante sulfato mucopolisacárido.
La heparina sódica es una sal sódica de glucosamina ácida extraída de la mucosa intestinal de cerdos o ganado. Es una sustancia mucopolisacárida. Trata diversas enfermedades complicadas por la coagulación intravascular diseminada temprana y previene la trombosis arterial y venosa y los pulmones. El supositorio, la heparina sódica, se encuentra actualmente en el mercado de productos crudos que van de 30.000 a 40.000 por kilogramo.
Proceso de heparina sódica:

Application of membrane technology in the separation and concentration of heparin sodium

Disolver:Tome el intestino delgado de cerdo fresco y raspe la mucosa de la superficie agregando agua en una proporción de uno a cuatro y revuelva para disolverlo. Ajuste el pH a aproximadamente 8,0 con aproximadamente 30% de hidróxido de sodio. Calentar en un baño de agua a 50 °C. Después de reposar durante 2 horas, retire las impurezas insolubles.
Hidrosis enzimática:La heparina existe en forma de un complejo heparina-proteína en animales. El componente proteico del complejo se elimina mediante hidrólisis enzimática o hidrólisis de sal y la heparina está libre. Se añade una pequeña cantidad de tripsina a la solución de heparina sódica para degradar poco de proteína que queda en la heparina en péptidos de molécula pequeña, que se disocian del complejo heparina-proteína, Y el exceso de proteína se elimina ajustando el valor de pH.
Centrifugación:Después de la centrifugación, se eliminan la mayoría de las impurezas particuladas y la grasa.
Recuperación de la adsorción de la resina:Ajuste el pH para 8,0 cuando la temperatura es de 55 grados, agregue la resina especial de heparina de sodio procesada D204, agite y absorba durante 8 horas, luego filtre y recoja la resina. Enjuague la resina adsorbida repetidamente con agua del grifo hasta que el agua se vuelva clara.
Alcohol precipitación y secado:Ajuste el pH de la solución de oxidación a 6,5 y agregue la misma cantidad de etanol 95% para la precipitación. El sobrenadante se extrae para obtener el precipitado, y el precipitado se añade alcohol anhidro o acetona lentamente a para la deshidratación, la temperatura se controla a 55 °C, Y el producto se seca al vacío durante más de 3 horas.

Conclusión:
En vista de los problemas de separación, purificación y concentración de productos de heparina/heparina sódica, tales como purificación y concentración de hidrolizado enzimático de heparina, desalinización y alta concentración de sal y alta COD aguas residuales de la cubierta, etc.
Las ventajas de la tecnología de separación de membrana son las siguientes:
Purificación y recuperación:La membrana cerámica puede interceptar completamente la proteína y otras sustancias macromoleculares en el sobrenadante centrífugo. Los métodos de separación tradicionales incluyen separación centrífuga, filtración de prensa de filtro, filtración de bolsa de tela, etc. Debido a la precisión de la filtración y otras razones, existen problemas como una menor eficiencia de adsorción y una vida útil más corta causada por impurezas macromoleculares que ingresan al proceso de resina posterior.
Desalinización y concentración:La membrana orgánica puede eliminar eficazmente el cloruro de sodio y otras sales en heparina sódica, y concentrar la heparina sódica para reemplazar el proceso tradicional de "dilución de agua", reduciendo en gran medida la cantidad de consumo de resina y el costo del tanque de apoyo, y reduciendo la descarga de aguas residuales.
Tratamiento de aguas residuales:La tecnología de integración de membrana logra el propósito de reciclaje y reutilización de aguas residuales, ahorro de energía.

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Aplicación de la tecnología de membrana en la separación y concentración de heparina sódica

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